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CAS No. : 17617-45-7

Biological Activity:Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC50 of 1.15 μM.

Research Area:Neurological Disease

Targets:Chloride Channel|GABA Receptor

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