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CAS No. : 17617-45-7
Biological Activity：Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC50 of 1.15 μM.
Research Area：Neurological Disease
Targets：Chloride Channel|GABA Receptor
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Natural Product Library;Lipid Compound Library;Neurotransmitter Receptor Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Plant-Sourced Natural Product Library;GABA Receptor Compound Library;
Related Small Molecules:SKF89976A hydrochloride;mGAT-IN-1;Alpidem;FG8119;Valerenic acid;Atractyloside potassium salt;Miltirone;MONNA;Etifoxine-13C,d3;Adipiplon;Gabazine;CaCCinh-A01;Broflanilide;Fluxametamide;ONO-8590580;γ-Aminobutyric acid-d6;Ginsenoside Rc;T16A(inh)-C01;Fipronil;p-Hydroxybenzaldehyde-13C;Niflumic acid-13C6;Lesogaberan hydrochloride;FG 7142;Isoguvacine hydrochloride;Guvacine ethyl ester;MRK-623
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