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GNF2133 hydrochloride
CAS No. : 2561414-57-9
Biological Activity:GNF2133 hydrochloride is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 hydrochloride shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 hydrochloride significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 hydrochloride has the potential for the research of type 1 diabetes.
Research Area:Metabolic Disease
Targets:DYRK
Related Small Molecules:Harmine hydrochloride;T025;ID-8;Dyrk1A-IN-2;GSK-626616;ARN25068;Haspin-IN-1;LDN-192960 hydrochloride;CLK-IN-T3;GNF4877;DYRKs-IN-2;JH-XIV-68-3;DYRKs-IN-1 hydrochloride;Protein kinase inhibitors 1 hydrochloride;KH-CB20;Dyrk1A/α-synuclein-IN-2;AZ191;Woodtide;CK2/ERK8-IN-1;DYRK1-IN-1;Dyrk1A-IN-5;ML167;tBID;Dyrk1A-IN-4;Mirk-IN-1;Dyrk1A-IN-1
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