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CAS No. : 78538-74-6
Biological Activity：FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex.
Research Area：Neurological Disease
Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Neurotransmitter Receptor Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;GABA Receptor Compound Library;Human Metabolite Library;
Related Small Molecules:SKF89976A hydrochloride;mGAT-IN-1;Alpidem;FG8119;Valerenic acid;Picrotoxinin;Miltirone;Etifoxine-13C,d3;Adipiplon;Gabazine;Broflanilide;Fluxametamide;ONO-8590580;γ-Aminobutyric acid-d6;Ginsenoside Rc;Fipronil;p-Hydroxybenzaldehyde-13C;Lesogaberan hydrochloride;Isoguvacine hydrochloride;Guvacine ethyl ester;MRK-623;Rilmazafone;(-)-α-Pinene;Alpidem-d14;17-PA
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