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Entacapone

CAS No. : 130929-57-6

Biological Activity：Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC₅₀ values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC₅₀s>50 µM). Entacapone can be used for the research of Parkinson’s disease. Entacapone serves as a inhibitor of FTO demethylation with an IC₅₀ of 3.5 μM, can be used for the research of metabolic disorders^[2].

Research Area：Neurological Disease

Targets：COMT

Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Neuronal Signaling Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Targeted Diversity Library;Rare Diseases Drug Library;Protein-protein Interaction Inhibitor Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;

Related Small Molecules:Nebicapone;Nitecapone;hMAO-B/MB-COMT-IN-2;Opicapone;Flopropione;Rosmarinic acid;5-Hydroxyferulic acid;Ro 41-0960;hMAO-B/MB-COMT-IN-1

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