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CAS No. : 695207-56-8

Biological Activity:BC-LI-0186 is a potent and selective inhibitor of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (IC50=46.11 nM). BC-LI-0186 competitively binds to the RagD interacting site of LRS (Kd=42.1 nM) and has on effects on LRS-Vps34, LRS-EPRS, RagB-RagD association, mTORC1 complex formation or the activities of 12 kinases. BC-LI-0186 can effectively suppress the activity of cancer-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 is a promising agent for lung cancer research[2].

Research Area:Cancer

Targets:Aminoacyl-tRNA Synthetase

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Anti-Lung Cancer Compound Library;Protein-protein Interaction Inhibitor Library;

Related Small Molecules:CB 168;GlyRS-IN-1;Gln-AMS;Epetraborole hydrochloride;Antibacterial agent 92;IleRS-IN-1;Leu-AMS;LysRs-IN-1;Aminoacyl tRNA synthetase-IN-1;Arg-AMS;Asp-AMS;Antibacterial agent 93;Isoleucyl tRNA synthetase-IN-2;LysRs-IN-2;Aminoacyl tRNA synthetase-IN-2;Antibacterial agent 91

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