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CAS No. : 1370544-73-2
Biological Activity：AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Differentiation Inducing Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Angiogenesis-Related Compound Library;Rare Diseases Drug Library;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Akt/NF-κB/JNK-IN-1;Cirsilineol;Ginsenoside F3;Perakizumab;PNRI-299;QNZ;CTX-471;Ac-YVAD-CHO;Sinulatumolin E;Deucravacitinib;Epobis;Mulberroside A;Sinulatumolin D;NFAT Transcription Factor Regulator-1;PDE4-IN-10;IL-17A antagonist 1;Kansuinine B;Ginsenoside Rc;TIC10;5(S)15(S)-DiHETE;IL-17A inhibitor 2;Teneliximab;Anti-Mouse IL-1b Antibody;Raleukin;Loganic acid 6′-O-β-D-glucoside;Ossirene;VGX-1027
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