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UF010
CAS No. : 537672-41-6
Biological Activity：UF010 is a potent and selective HDAC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)
Target: HDAC
in vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer
cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways.
Research Area：Cancer
Targets：HDAC
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Liver Cancer Compound Library ;Osteogenesis Compound Library;
Related Small Molecules:Pivanex;Crotonoside;MPT0B390;RSC133;HDAC1/6-IN-1;HDAC/HSP90-IN-4;JPS014;HDAC-IN-4;HDAC-IN-27;1-Alaninechlamydocin;SKLB-23bb;Tacedinaline;HPOB;HDAC-IN-28;CG347B;Tubacin;HDAC10-IN-1;HDAC6-IN-6;Resminostat;Alteminostat;HDAC-IN-47;Ivaltinostat formic;Crebinostat;FNDR-20123 free base;Homobutein;Ac-Lys-AMC;HDACs/mTOR Inhibitor 1;BRD73954
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