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Trimethylamine N-oxide
CAS No. : 1184-78-7
Biological Activity：Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[2][3].
Research Area：Inflammation/Immunology|Cardiovascular Disease
Targets：Reactive Oxygen Species|TGF-beta/Smad|NOD-like Receptor (NLR)|Endogenous Metabolite
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;TGF-beta/Smad Compound Library;Wnt/Hedgehog/Notch Compound Library;Natural Product Library;Human Endogenous Metabolite Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Ferroptosis Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Gut Microbial Metabolite Library;Microbial Metabolite Library;Angiogenesis-Related Compound Library;Mitochondria-Targeted Compound Library;Transcription Factor-Targeted Library;Food Additive Library ;Food-Sourced Compound Library ;Anti-Liver Cancer Compound Library ;Antidepressant Compound Library;Human Metabolite Library;Osteogenesis Compound Library;
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