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N-Desmethyltamoxifen hydrochloride
CAS No. : 15917-65-4
Biological Activity：N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[2][3].
Research Area：Cancer
Targets：Drug Metabolite|PKC|Estrogen Receptor/ERR|Endogenous Metabolite
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