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JNK3 inhibitor-4

CAS No. : 2409109-65-3

Biological Activity：JNK3 inhibitor-4 is a potent inhibitor of JNK3 (IC₅₀=1.0 nM) based on 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile. JNK3 inhibitor-4 shows excellent selectivity over other protein kinases including isoforms JNK1 (IC₅₀=143.9 nM) and JNK2 (IC₅₀=298.2 nM). JNK3 inhibitor-4 has neuroprotective effect and predicated blood-brain barrier permeability.

Research Area：Neurological Disease

Targets：JNK

Related Small Molecules:Akt/NF-κB/JNK-IN-1;JNK3 inhibitor-2;JIP-1(153-163) TFA;TOPK-p38/JNK-IN-1;JNK-IN-8;Sesamolin;Astragaloside IV;Tomatidine;(-)-Zuonin A;JNK3 inhibitor-1;Polyphyllin I;IQ-3;MAPK-IN-1;CT1-3;SR-3306;JNK3 inhibitor-3;BI-78D3;DB07268;JNK3 inhibitor-5;Guggulsterone;Urolithin B;Loureirin B;JNK-IN-7;MPT0B392;TCS JNK 5a;Anisomycin;IMM-H007

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