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Itraconazole

CAS No. : 84625-61-6

Biological Activity：Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor^[2][3][4].

Research Area：Infection|Cancer

Targets：Fungal|Autophagy|Hedgehog|Bacterial|Antibiotic|Cytochrome P450

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Metabolism/Protease Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Antiviral Compound Library;CNS-Penetrant Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Antioxidant Compound Library;Oxygen Sensing Compound Library;Antifungal Compound Library;Antibacterial Compound Library;NMPA-Approved Drug Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Antibiotics Library;Anti-Breast Cancer Compound Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;Anti-Colorectal Cancer Compound Library ;Children’s Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Non-steroidal Anti-Inflammatory Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:Antifungal agent 20;Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Monascorubrin;SR9186;Azlocillin sodium salt;AMG-208;Herbimycin A;Antibacterial agent 45;Debneyol;Leucomycin;Isouvaretin;Haloprogin;Antibacterial agent 99;Vidarabine monohydrate;Nafcillin;Antitubercular agent-28;Ochromycinone;Staurosporine;Nucleocidin;(±)-Leucine-13C-1

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