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iFSP1

CAS No. : 150651-39-1

Biological Activity：iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC₅₀ of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A).

Research Area：Cancer

Targets：Ferroptosis

Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Ferroptosis Compound Library;Targeted Diversity Library;Cuproptosis Compound Library;

Related Small Molecules:CIL56;DB0614;Ciclopirox-d11;Ciclopirox olamine;Curcumin;(-)-Epicatechin;Eugenol-d3;Artemisinin-d3;MMRi62;UAMC-3203;L-Glutamic acid-15N,d5;Chalcones A-N-5;Pifithrin-β hydrobromide;PD146176;Roxadustat;Matrine;Liproxstatin-1;Hemin;L-Glutamic acid monosodium salt;Acetylcysteine-d3;Pifithrin-α hydrobromide

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