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4-Hydroperoxy cyclophosphamide
CAS No. : 39800-16-3
Biological Activity：4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders.
Research Area：Inflammation/Immunology
Targets：Drug Metabolite|DNA Alkylator/Crosslinker|Reactive Oxygen Species|Apoptosis
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