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Facinicline hydrochloride
CAS No. : 677305-02-1
Biological Activity：Facinicline hydrochloride (RG3487 hydrochloride) is an orally active nicotinic α7 receptor partial agonist, with a Ki of 6 nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimotor gating in rodents. Facinicline hydrochloride (RG3487 hydrochloride) shows high affinity (antagonist) to 5-HT3Rs with a Ki value of 1.2 nM.
Research Area：Neurological Disease
Targets：nAChR|5-HT Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Orally Active Compound Library;Neurotransmitter Receptor Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;5-HT Receptor Compound Library;Coagulation and Anti-coagulation Compound Library;
Related Small Molecules:F 13714;Mosapride-d5;Spinosad;Nuciferine;Pyrantel;Renzapride;LY 344864 racemate;Harmine hydrochloride;Valerenic acid;Arotinolol;Melitracen-d6 hydrochloride;WAY-100635;Nelotanserin;Flupentixol-d4 dihydrochloride;Cariprazine-d6 hydrochloride;Tetrahydro-β-carboline;NS 9283;CP-809101;Myosmine-d4
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