Anle138b

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Anle138b

CAS No. : 882697-00-9

Biological Activity:Anle138b, an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Anle138b strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Anle138b has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology[2].

Research Area:Neurological Disease

Targets:Amyloid-β

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Related Small Molecules:β-Amyloid (13-27);Saikosaponin C;β-Amyloid (1-42), (rat/mouse) (TFA);β-Amyloid (12-28) (TFA);BuChE-IN-5;Ginsenoside Rg1;MDR-1339;β-Amyloid (11-22);20(S)-Ginsenoside Rg3;β-Amyloid (31-35);Aβ-IN-1;Qingyangshengenin B;JNJ-40418677;HDAC6-IN-6;β-Amyloid (1-37) (human);CGP52411;Astrophloxine;γ-Secretase modulator 12;δ-Secretase inhibitor 11;BuChE-IN-2;FPS-ZM1;BChE-IN-8;4-(6-Bromo-2-benzothiazolyl)benzenamine;Timosaponin BII;Valiltramiprosate;Azeliragon;CRANAD-2

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