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Tenofovir exalidex

CAS No. : 911208-73-6

Biological Activity：Tenofovir exalidex (CMX157) is a lipid conjugate of the acyclic nucleotide analog Tenofovir with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. Tenofovir exalidex is active against all major subtypes of HIV-1 and HIV-2 in fresh human PBMCs and against all HIV-1 strains evaluated in monocyte-derived macrophages, with EC₅₀s ranging between 0.2 and 7.2 nM. CMX157 is orally available and has no apparent toxicity. Tenofovir exalidex also shows antiviral activity against HBV^[2]^[3].

Research Area：Infection

Targets：Nucleoside Antimetabolite/Analog|HIV|HBV

Related Small Molecules:m7GpppCpG;7-TFA-ap-7-Deaza-dA;HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;Triptonine B;FC131;Peritassine A;m7GpppUmpG;DMT-2′-F-Bz-dA;Flavopiridol;DVR-01;TAT (48-57);FGI-106 tetrahydrochloride;(Z)-9-Propenyladenine;Cytidine-d1;Apabetalone

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