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Sunvozertinib
CAS No. : 2370013-12-8
Biological Activity：Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52).
Research Area：Cancer
Targets：EGFR|Btk
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Anti-Hepatitis C Virus Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:JAK3/BTK-IN-1;NSC81111;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;Osimertinib-13C,d3;Elsubrutinib;EGFR-IN-5;FGFR2-IN-3;ARQ 531;PF-06250112;PCI 29732;Genistein;Epertinib hydrochloride;UNC-CA359;Osimertinib mesylate;AV-412 free base;Nelipepimut-S;Falnidamol;HER2-IN-6;PROTAC EGFR degrader 7;CHMFL-EGFR-202;Avitinib;Naquotinib;RN486
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