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Biological Activity:(S)-GNE-987 (compound 4), the GNE-987 (a chimeric BET degrader) hydroxy-proline epimer, abrogates binding to von Hippel-Lindau and does not degrade BRD4 protein. (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).

Research Area:Cancer

Targets:Epigenetic Reader Domain|PROTACs

Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;RVX-297;BRD4 Inhibitor-19;UNC6349 (Ket2);PROTAC VEGFR-2 degrader-2;Curcumin;GSK6853;dTAGV-1-NEG;CCT367766 formic;GSK4028;SR-0813;HDAC6 degrader-1;PROTAC Axl Degrader 2;Inobrodib;PhosTAC7;MS98;Apabetalone;OF-1;I-CBP112;JPS014;PROTAC PARP1 degrader;A-485;MD-224;PLX51107;FKBP12 PROTAC dTAG-7;I-BET151;SJ10542;MS8815;GSK040

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