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CAS No. : 17692-51-2

Biological Activity:Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation[2][3].

Research Area:Neurological Disease

Targets:Dopamine Receptor|5-HT Receptor|Sodium Channel

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;FDA-Approved Drug Library;Drug Repurposing Compound Library;Neurotransmitter Receptor Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Neuroprotective Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Protein-protein Interaction Inhibitor Library;Sodium Channel Blocker Library;5-HT Receptor Compound Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Lu AE98134;Bromopride-d3;Zandatrigine;Nuciferine;Glaucine;Veratridine;Renzapride;SB-277011 dihydrochloride;Brompheniramine-d6 maleate;GX-674;LY 344864 racemate;Harmine hydrochloride;Dibucaine;MIF-1 TFA;Valerenic acid;Arotinolol;Sulpiride

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