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LEO 39652

CAS No. : 1445656-91-6

Biological Activity：LEO 39652 is a dual-soft PDE4 inhibitor with IC₅₀s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC₅₀ value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) .

Research Area：Inflammation/Immunology

Targets：Phosphodiesterase (PDE)

Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Clinical Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:Senazodan hydrochloride;(E/Z)-HA155;Enpp/Carbonic anhydrase-IN-1;ATX inhibitor 22;Carbazeran citrate;Bay 60-7550;BC11-38;Deltarasin hydrochloride;Glaucine;Ziritaxestat;Udenafil-d7;D159687;ITI-214;PDE10-IN-5;ICI 153110;Furamidine dihydrochloride;ML-030;PDE4-IN-10;Mirodenafil-d7 dihydrochloride;PDE1-IN-4;PDE4B-IN-3;Cirsimarin;PF-03049423;IBMX;Pimobendan;Gisadenafil besylate;S32826 disodium

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