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BMS-986318
CAS No. : 2314378-09-9
Biological Activity：BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis.
Research Area：Metabolic Disease
Targets：FXR
Related Small Molecules:DY268;FXR agonist 4;Chenodeoxycholic Acid-d9;EDP-305;Turofexorate isopropyl;Tauro-Obeticholic acid-d5 sodium;Chenodeoxycholic acid-13C;LY2562175;INT-767;BAR502;Glyco-obeticholic acid-d5;NR1H4 activator 1;NDB;BMS-986339;FXR antagonist 1;Guggulsterone;Forskolin;Obeticholic acid-d5;Chenodeoxycholic acid-d5;Nidufexor;Tauro-β-muricholic acid sodium;Obeticholic acid;T0901317
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