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AZ3976

CAS No. : 1418747-15-5

Biological Activity：AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC₅₀ value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC₅₀ of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay.

Research Area：Cardiovascular Disease

Targets：PAI-1

Related Small Molecules:UKI-1;TM5441;UK-371804;ZK824190 hydrochloride;Diaplasinin;Tiplaxtinin;Loureirin B;28-O-β-D-Glucopyranosyl pomolic acid;ZK824859;Toddalolactone;ACT001;Geodin;Angstrom6;Aleplasinin;Anecortave acetate;TM5275 sodium;Upamostat;CDE-096;TM5007

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