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Adezmapimod hydrochloride
CAS No. : 869185-85-3
Biological Activity：Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride is an autophagy and mitophagy activator.
Research Area：Inflammation/Immunology|Cancer
Targets：Autophagy|p38 MAPK|Mitophagy
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Anti-Lung Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Mitochondria-Targeted Compound Library;Antidepressant Compound Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:Curcumin;SB-747651A dihydrochloride;Dehydrocorydaline;Melatonin-d3;SKF-86002 dihydrochloride;Pexmetinib;Resveratrol;SB 242235;Clioquinol;TA-01;Anti-inflammatory agent 7;MW-150;VX-702;R1487 Hydrochloride;Betulinic acid;Matrine;Sulfosuccinimidyl oleate;Hemin;MBP MAPK Substrate;Isoliquiritin apioside;Sesamolin;Polydatin;AICAR
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