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AChE/GSK-3β-IN-1

CAS No. : 2412364-73-7

Biological Activity：AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC₅₀ values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research.

Research Area：Neurological Disease

Targets：Microtubule/Tubulin|GSK-3|Cholinesterase (ChE)|ROS Kinase

Related Small Molecules:TCS2002;Tirbanibulin dihydrochloride;AR-A014418;Tilavonemab;Piperilate;Tau tracer 1;BuChE-IN-5;Dolastatin 10;AChE/BChE-IN-10;Ceratamine A;Timosaponin AIII;GSK 3 Inhibitor IX;Batabulin sodium;Trimyristin;AChE-IN-10;OXi8007;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;Antitumor agent-68;Sinapine thiocyanate;sEH/AChE-IN-1;Dictyostatin;Tubulin inhibitor 6;AChE-IN-11;Oryzalin

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