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RO8191

CAS No. : 691868-88-9

Biological Activity：RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC₅₀ of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity^[2].

Research Area：Infection

Targets：IFNAR|JAK|HCV|STAT|HBV

Related Small Molecules:AZ-3;AX-024;JAK3/BTK-IN-1;HCV-IN-30;Cirsilineol;Ochromycinone;AT9283;C188-9;Benzene hexabromide;Ginsenoside F3;STAT3-IN-10;(E/Z)-Zotiraciclib;HCV-IN-38;JAK-IN-10;C188;Baricitinib-d3;Sennidin A;JAK3-IN-6;Niclosamide monohydrate;HCV-IN-31;Radalbuvir;Grazoprevir potassium salt;DVR-01;FGI-106 tetrahydrochloride;STAT3-IN-1

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