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PD-089828

CAS No. : 179343-17-0

Biological Activity：PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR (IC₅₀s=0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of c-Src tyrosine kinase (IC₅₀=0.18 µM). PD-089828 also inhibits MAPK with an IC₅₀ of 7.1 µM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.

Research Area：Cancer

Targets：EGFR|Src|FGFR|PDGFR

Related Small Molecules:KB SRC 4;Tirbanibulin dihydrochloride;NSC81111;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;Bafetinib;Osimertinib-13C,d3;p60c-src substrate II;Henatinib;EGFR-IN-5;FGFR2-IN-3;Flumatinib mesylate;IHMT-TRK-284;Caffeic acid-pYEEIE TFA;Ferulic acid-13C3;PDGFRα/FLT3-ITD-IN-2;Genistein;Epertinib hydrochloride;PP2;FGFR-IN-7;PP58;UNC-CA359;Chiauranib;Osimertinib mesylate

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