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GNF-7

CAS No. : 839706-07-9

Biological Activity：GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC₅₀s of 133 nM and 61 nM for Bcr-Abl^WT and Bcr-Abl^T315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC₅₀s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies^[2]^[3].

Research Area：Cancer

Targets：Ack1|Bcr-Abl

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Cytoskeleton Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Blood Cancer Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Targeted Diversity Library;Anti-Prostate Cancer Compound Library;

Related Small Molecules:AT9283;Bafetinib;Pivanex;SNIPER(ABL)-039;Flumatinib mesylate;IHMT-TRK-284;KRCA-0008;SNIPER(ABL)-049;Olverembatinib;GNF-2;CT-721;SNIPER(ABL)-015;GNF-5;BCR-ABL-IN-4;SNIPER(ABL)-033;CHMFL-ABL-039;BCR-ABL-IN-6;c-ABL-IN-2;SNIPER(ABL)-058;ON 146040;HG-7-85-01;CHMFL-ABL/KIT-155;Radotinib-d6;BCR-ABL-IN-1

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