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Glibenclamide
CAS No. : 10238-21-8
Biological Activity：Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].
Research Area：Metabolic Disease
Targets：CFTR|Autophagy|Potassium Channel|P-glycoprotein|Mitochondrial Metabolism
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