Adezmapimod

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Adezmapimod

CAS No. : 152121-47-6

Biological Activity:Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator.

Research Area:Inflammation/Immunology|Cancer

Targets:Autophagy|p38 MAPK|Mitophagy

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Anti-Lung Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Mitochondria-Targeted Compound Library;Antidepressant Compound Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;

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