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CAS No. : 718612-51-2

Biological Activity:SN-38-d5 is deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[2][3][4].

Research Area:Cancer

Targets:Topoisomerase|Autophagy|ADC Cytotoxin

Related Small Molecules:Sandramycin;Gepotidacin;Topoisomerase I/II inhibitor 3;(R)-Camptothecin-d5;Dolastatin 10;Topoisomerase II inhibitor 8;FLT3-IN-13;INX-SM-56;TP3011;TAS-103 dihydrochloride;DC10SMe;Rebeccamycin;Duocarmycin TM;Fmoc-MMAE;Taltobulin;N-Me-L-Ala-maytansinol;CC-885-CH2-PEG1-NH-CH3;AZD5099;TP0480066;Topoisomerase I inhibitor 4;Camptothecin;Corydamine;SW044248;Maytansinol

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