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NF157
CAS No. : 104869-26-3
Biological Activity：NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 µM, 170 µM for P2Y11 (Ki=44.3 nM), P2Y1 (Ki=187 µM), P2Y2 (Ki=28.9 µM), respectively. NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA)[2].
Research Area：Inflammation/Immunology
Targets：P2Y Receptor
Related Small Molecules:YM-254890;BPTU;Uridine 5′-diphosphoglucose disodium salt;AZD1283;Antiplatelet agent 1;NF546;MRS2395;PSB-1114 tetrasodium;Vicagrel;Cangrelor tetrasodium;MRS2179 tetrasodium hydrate;PSB-0739;PIT;MRS2279;MRS2768 tetrasodium salt;PPTN hydrochloride;PSB 0474
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