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NB-360
CAS No. : 1262857-73-7
Biological Activity：NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[2].
Research Area：Inflammation/Immunology|Neurological Disease
Targets：Beta-secretase
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Neuronal Signaling Compound Library;CNS-Penetrant Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;
Related Small Molecules:LY2886721;BACE1-IN-9;β-Secretase Inhibitor II;Cassiaside;Glabrolide;OM99-2;JNJ-67569762;β-Secretase Inhibitor III;BACE1-IN-12;BACE1-IN-11;Multitarget AD inhibitor-1;BACE-1 inhibitor 1;BACE1-IN-8;AM-6494;LX2343;LY2811376;COX-2-IN-22;AZD3839 free base;Aloenin;β-Secretase Inhibitor IV;AChE/BChE/BACE-1-IN-2;BACE1-IN-4;Sophoflavescenol;Aloeresin D;BACE-IN-1;BACE-1 inhibitor 2;Epiberberine chloride;BACE1-IN-2
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