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bpV(phen) trihydrate
CAS No. : 171202-16-7
Biological Activity：bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[2][3][4][5].
Research Area：Cancer|Infection|Metabolic Disease|Inflammation/Immunology
Targets：Parasite|PTEN|Phosphatase|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Anti-Pancreatic Cancer Compound Library;Phosphatase Inhibitor Library;Antiparasitic Compound library;Anti-Cancer Metabolism Compound Library;Glucose Metabolism Compound Library;Antidepressant Compound Library;
Related Small Molecules:Physalin A;(+)-Isopulegol;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;BJE6-106;Dinaciclib;GNF362;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin
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