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BI-1622
CAS No. : 2681392-19-6
Biological Activity：BI-1622 is an orally active, potent and highly selective HER2 (ERBB2) inhibitor, with an IC50 of 7 nM. BI-1622 shows greater than 25-fold selectivity over EGFR. BI-1622 shows high antitumor efficacy in vivo in xenograft mouse tumor models with engineered H2170 and PC9 cells and had a favorable drug metabolism and pharmacokinetics profile.
Research Area：Cancer
Targets：EGFR|JAK|Itk|Raf|PI4K|CDK|Btk
Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;MAPK Compound Library;PI3K/Akt/mTOR Compound Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Anti-Hepatitis C Virus Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Glucose Metabolism Compound Library; Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:AZ-3;DB0614;Avutometinib;JAK3/BTK-IN-1;NSC81111;Dinaciclib;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;AT9283;SNS-032;ITK antagonist;CC-671;Benzene hexabromide;(E/Z)-Zotiraciclib;AZ 628;Osimertinib-13C,d3;CDK1-IN-4;CCT-251921;JAK-IN-10;Elsubrutinib;BS-181;EGFR-IN-5;FGFR2-IN-3;Samuraciclib hydrochloride hydrate;Baricitinib-d3;ARQ 531
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