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6,8-Diprenylnaringenin

CAS No. : 68236-11-3

Biological Activity：6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and ³H-Methotrexate transport (IC₅₀=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin^[2].

Research Area：Cancer|Metabolic Disease

Targets：BCRP

Related Small Molecules:PCI 29732;Triclabendazole sulfoxide;Elacridar;P-gp/BCRP-IN-1;YHO-13351;CP-100356 hydrochloride;PD166326;Fumitremorgin C;UR-MB108;Zamicastat;Ko 143;KS176;ML753286;ML230;Triclabendazole sulfoxide-d3;Ac32Az19;FD 12-9;Triclabendazole sulfoxide-13C,d3;YHO-13177

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