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CAS No. : 500992-11-0
Biological Activity：Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.
Research Area：Neurological Disease
Related Small Molecules:Carboxy-PTIO potassium;Valeriandoid F;Ciwujianoside C3;CIQ;NOS-IN-3;Regaloside A;Quinolinic acid-d3;Aminopicoline;1-Aminocyclobutanecarboxylic acid;Glycine-1-13C,15N;trans-Isoferulic acid;DETA NONOate;Chondroitin sulfate;ZL006;PYD-106;NMDA-IN-2;3-Bromo-7-nitroindazole;JAMI1001A;(S)-Willardiine;Fanapanel;(S)-AMPA;α7 nAchR-JAK2-STAT3 agonist 1;Asperuloside;L-Glutamic acid-15N,d5;PDZ1 Domain inhibitor peptide TFA;Ifenprodil tartrate;Rislenemdaz;Coluracetam
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