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CAS No. : 362505-84-8
Biological Activity：Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC50 values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo.
Research Area：Cancer|Metabolic Disease
Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;
Related Small Molecules:Calpeptin;Cathepsin G Inhibitor I;Gly-Phe-β-naphthylamide;Z-FY-CHO;Balicatib;Cathepsin D and E FRET Substrate;N-CBZ-Phe-Arg-AMC TFA;LV-320;Z-LVG-CHN2;ONO-5334;VBY-825;L-873724;Z-WEHD-FMK;Odanacatib;Atg4B-IN-2;Cysteine Protease inhibitor;KGP94;E-64;Cathepsin L-IN-2;LmCPB-IN-1;MK-0674;MIV-247;Aurantiamide acetate;SID 26681509;ALLM;LY 3000328;Cathepsin C-IN-3;Cathepsin C-IN-5;K777
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