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Relacatib

CAS No. : 362505-84-8

Biological Activity：Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with K_i values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC₅₀ values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo^[2].

Research Area：Cancer|Metabolic Disease

Targets：Cathepsin

Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;

Related Small Molecules:Calpeptin;Cathepsin G Inhibitor I;Gly-Phe-β-naphthylamide;Z-FY-CHO;Balicatib;Cathepsin D and E FRET Substrate;N-CBZ-Phe-Arg-AMC TFA;LV-320;Z-LVG-CHN2;ONO-5334;VBY-825;L-873724;Z-WEHD-FMK;Odanacatib;Atg4B-IN-2;Cysteine Protease inhibitor;KGP94;E-64;Cathepsin L-IN-2;LmCPB-IN-1;MK-0674;MIV-247;Aurantiamide acetate;SID 26681509;ALLM;LY 3000328;Cathepsin C-IN-3;Cathepsin C-IN-5;K777

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