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Nebentan

CAS No. : 403604-85-3

Biological Activity：Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ET_A receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo^[2].

Research Area：Inflammation/Immunology|Cardiovascular Disease

Targets：Endothelin Receptor

Related Small Molecules:BQ-788;[Asn18] Endothelin-1, human;Endothelin-3, human, mouse, rabbit, rat TFA;IRL 2500;Sarafotoxin S6c;Sarafotoxin S6a;ANP (1-30), frog;IRL-1620 TFA;Tezosentan;ACT-373898;Ro 46-2005;Ro 46-8443;[Ala2] Endothelin-3, human;ZD-1611;PD-159020;Aminaftone;Aprocitentan-d4;Endothelin 1 (swine, human);Atrial Natriuretic Peptide (ANP) (1-28), rat;Carperitide acetate;[Ala1,3,11,15]-Endothelin (53-63) (TFA);Sparsentan-d5;BQ-123 TFA

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