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Keap1-Nrf2-IN-1 TFA
Biological Activity：Keap1-Nrf2-IN-1 TFA (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2-IN-1 TFA activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models.
Research Area：Metabolic Disease|Inflammation/Immunology
Targets：Keap1-Nrf2
Related Small Molecules:Mangiferin;Antioxidant agent-5;Curcumin;Antroquinonol;Resveratrol;NXPZ-2;Eriodictyol;ML334;S-Allylmercaptocysteine;NK-252;Ginsenoside Rh3;4-Hydroxyphenylacetic acid-d6;Kinsenoside;Pyridoxine-d3 hydrochloride;Pyridoxine;Carnosol;Corynoline;5,7-Dihydroxychromone;Carlinoside;Pyridoxine-d2 hydrochloride;Pyridoxine-13C4 hydrochloride;4-Hydroxyphenylacetic acid;Poricoic acid A;Hinokitiol;Nrf2-ARE/hMAO-B/QR2 modulator 1;CBR-470-2;Danshensu
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