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GLL398

CAS No. : 2077980-80-2

Biological Activity：GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC₅₀ value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC₅₀= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models.

Research Area：Cancer

Targets：Estrogen Receptor/ERR

Related Small Molecules:DS20362725;LSD1/ER-IN-1;Giredestrant;Avobenzone;Estriol-d3;Chrysin;ERRγ Inverse Agonist 1;(R)-DPN;MPP hydrochloride;GPR30 agonist-1;Diethylstilbestrol;Endoxifen;Glicoricone;ERB-196;Dihydroresveratrol;FLTX1;(Rac)-Hexestrol-d6

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