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Fustin

CAS No. : 20725-03-5

Biological Activity：Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) can be used for Alzheimer’s disease research.

Research Area：Neurological Disease

Targets：mAChR|Amyloid-β|Cholinesterase (ChE)

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