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CAS No. : 20725-03-5

Biological Activity:Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3′,4′-Tetrahydroxyflavanone) can be used for Alzheimer’s disease research.

Research Area:Neurological Disease

Targets:mAChR|Amyloid-β|Cholinesterase (ChE)

Related Small Molecules:VU0357017 hydrochloride;β-Amyloid (13-27);Saikosaponin C;TBPB;Imidafenacin;β-Amyloid (1-42), (rat/mouse) (TFA);Sabcomeline;Piperilate;β-Amyloid (12-28) (TFA);MK-6884;BuChE-IN-5;Brompheniramine-d6 maleate;Ginsenoside Rg1;MDR-1339;AChE/BChE-IN-10;Timosaponin AIII;Trimyristin;AChE-IN-10;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;β-Amyloid (11-22);Sinapine thiocyanate;sEH/AChE-IN-1;AChE-IN-11

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