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AChE/BChE/BACE-1-IN-1
CAS No. : 1321361-13-0
Biological Activity：AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential.
Research Area：Neurological Disease
Targets：Beta-secretase|Cholinesterase (ChE)|ROS Kinase
Related Small Molecules:LY2886721;Piperilate;BACE1-IN-9;BuChE-IN-5;AChE/BChE-IN-10;Timosaponin AIII;Trimyristin;AChE-IN-10;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;Sinapine thiocyanate;sEH/AChE-IN-1;AChE-IN-11;Heliosupine;(-)-Cyclopenin;Taletrectinib;Leptomerine;eeAChE-IN-1;HDAC6-IN-6;β-Secretase Inhibitor II
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