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Thiolutin

CAS No. : 87-11-6

Biological Activity：Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation^[2].

Research Area：Infection|Metabolic Disease

Targets：Bacterial|Antibiotic|Endogenous Metabolite

Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;

Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;Sandramycin;LLO (91-99);N-Acetyl-L-glutamic acid-d5;Gepotidacin;(3R,5S)-3-Hydroxy Cotinine-d3;Biliverdin hydrochloride;Oritavancin;Monascorubrin;Azlocillin sodium salt;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid hydrochloride;Docosanoic acid-d3;Choline-d6 chloride;Herbimycin A;Pregnenolone monosulfate sodium

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