June 2021

Or cancer sufferers [13,14]. Additionally to oncogenic activation and DNA damage response, senescence is modulated by a plethora of other variables, and probably the most critical ones is oxygen level present in the tissues [1517]. It is essential to note that the majority of the cell culturing conditions do not represent the accurate oxygen state […]

Oliferative organs in the 3rd generation and embryonic developmental defects and sterility within the 6th generation [236]. One of the most striking distinction is that plants harbouring short telomeres have an extended life span and remain metabolically active whilst telomere dysfunction in mice induces metabolic and mitochondrial compromise [27]. To date, the particular plant mechanisms […]

Ation of FANCD2 foci with replication forks, cells have been labeled with BrdU for 20 min. No less than person 10 fields were counted and SD presented as error bars (P 0.001).the indicated times of exposure (6 and 24 hours), whole cell lysates have been normalized for protein concentrations and probed for different DDR proteins. […]