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HDAC/HSP90-IN-4

Biological Activity：These compounds have strong hdac and hsp90 inhibitory activities. Compound 20 (HDAC ic₅₀   =   194   nm; Hsp90 α < b> Ic₅₀ =   153   nm) and compound 26 ((HDAC ic₅₀=   360   nm; Hsp90 α < b> Ic₅₀   =   77   nm) shows the strongest HDAC and HSP90 α Inhibitory activity. Both compounds can induce hsp90 expression and down regulate hsp90 client proteins, which play an important role in regulating the survival and invasion of cancer cells.

Research Area：Cancer

Targets：HDAC|HSP

Related Small Molecules:6BrCaQ;Pivanex;116-9e;Crotonoside;MPT0B390;RSC133;HDAC1/6-IN-1;Paeoniflorin;Debio 0932;JPS014;HDAC-IN-4;MKT-077;Ethoxyquin;Cemdomespib;HDAC-IN-27;1-Alaninechlamydocin;SKLB-23bb;Tacedinaline;HPOB;HDAC-IN-28;CG347B;Tubacin;HDAC10-IN-1;Apatorsen;HS-131;CH5138303;HDAC6-IN-6

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