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UNC2025 hydrochloride

CAS No. : 2070015-17-5

Biological Activity：UNC2025 hydrochloride is a potent, ATP-competitive, and highly orally active Mer/Flt3 inhibitor with IC₅₀ values of 0.74 nM and 0.8 nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl (IC₅₀= 122 nM; K_i = 13.3 nM). UNC2025 hydrochloride exhibits an excellent PK properties, and can be used for the investigation of acute leukemia.

Research Area：Cancer

Targets：FLT3

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Orally Active Compound Library;Anti-Blood Cancer Compound Library;Anti-Prostate Cancer Compound Library;

Related Small Molecules:AT9283;(E/Z)-Zotiraciclib;Crotonoside;FLT3-IN-13;PDGFRα/FLT3-ITD-IN-2;FLT3/CDK4-IN-1;HP1142;ENMD-2076 Tartrate;ATH686;AZD2932;AKN-028 acetate;FLT3-IN-3;Tandutinib;Gilteritinib-d8;PF 477736;(R)-3-Hydroxy Midostaurin;BSc5371;OTS447;PDGFRα/FLT3-ITD-IN-1;TAK-659 hydrochloride;FLT3-IN-4;JNJ-47117096 hydrochloride;FLT3-IN-14;MAX-40279 hemiadipate

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