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Topoisomerase I/II inhibitor 2
Biological Activity：Topoisomerase I/II inhibitor 2 (compound 1a) is a potent Topoisomerase inhibitor (IC50= 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells). Topoisomerase I/II inhibitor 2 has dual inhibition on DNA topoisomerase I/II, also can obviously reduce the growth of xenograft tumor in mice model. Topoisomerase I/II inhibitor 2 has the potential value in treating liver cancer.
Research Area：Cancer
Targets：Topoisomerase
Related Small Molecules:Gepotidacin;Topoisomerase I/II inhibitor 3;(R)-Camptothecin-d5;Topoisomerase II inhibitor 8;FLT3-IN-13;TP3011;TAS-103 dihydrochloride;Rebeccamycin;AZD5099;TP0480066;Topoisomerase I inhibitor 4;Camptothecin;Corydamine;SW044248;9-Hydroxyellipticine hydrochloride;Flumequine-13C3;Trovafloxacin mesylate;Topoisomerase II inhibitor 12;Topoisomerase I inhibitor 3;Berberine sulfate;Betulinic acid;Hycanthone;Niranthin
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