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THK-5117
CAS No. : 1374107-54-6
Biological Activity：THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates. 18F-THK-5117 has the potential to act as a tau imaging PET probe.
Research Area：Neurological Disease
Targets：Microtubule/Tubulin
Related Small Molecules:Tirbanibulin dihydrochloride;Tilavonemab;Tau tracer 1;Dolastatin 10;Ceratamine A;Batabulin sodium;OXi8007;Antitumor agent-68;Dictyostatin;Tubulin inhibitor 6;Oryzalin;Tubulin inhibitor 25;Fmoc-MMAE;Taltobulin;Tubulin inhibitor 16;Epothilone B;TN-16;Maytansinol;VcMMAE;Mc-MMAE;SS28;Tubulysin H;Fosbretabulin disodium;Tubulin polymerization-IN-7
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