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Rofecoxib-d5
CAS No. : 544684-93-7
Biological Activity：Rofecoxib D5 (MK 966 D5) is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells)[2].
Research Area：Inflammation/Immunology|Cancer
Targets：COX
Related Small Molecules:Akt/NF-κB/JNK-IN-1;COX-2/5-LOX-IN-3;Ampyrone;COX-2-IN-24;Zaltoprofen-d7;α-Vitamin E-d6;1-Hydroxy-ibuprofen;Asaraldehyde;(-)-Epicatechin;20(S)-Ginsenoside Rg3;Ginsenoside Rd;Nimesulide D5;COX-2/5-LOX-IN-1;S-(+)-Marmesin;Tazofelone;Catechin-13C3;Diclofenac-d4;Proglumetacin;Ethoxycoronarin D;Phenidone;Iguratimod;Fenbufen-d9;COX-2-IN-6;Anti-inflammatory agent 9;Pentagamavunon-1;Aceclofenac
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