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Guggulsterone
CAS No. : 95975-55-6
Biological Activity：Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively[2].
Research Area：Cancer
Targets：Akt|Autophagy|FXR|Caspase|Apoptosis|JNK
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Metabolism/Protease Compound Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Natural Product Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Lipid Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Glutamine Metabolism Compound Library;Traditional Chinese Medicine Active Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Glucose Metabolism Compound Library;Food-Sourced Compound Library ;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Cancer Natural Product Library;Anti-inflammatory Traditional Chinese Medicine Active Compound Library;Plant-Sourced Natural Product Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Nuclear Receptor Compound Library;Osteogenesis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Akt/NF-κB/JNK-IN-1;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;JNK3 inhibitor-2;Lobetyolin;BJE6-106;DY268;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib
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